Using our unique Chromoprobe process, multiple probes are reversibly bound to a glass slide providing a convenient screening tool for genetic abnormalities across multiple chromosomes. Key applications include detection of chromosomal rearrangements and as a diagnostic/ prognostic tool in the detection of various leukamia’s.
Multiprobe* Overview
The Chromoprobe Multiprobe System is an extension of Cytocell’s proprietary Chromoprobe technology, whereby DNA FISH probes are reversibly bound to the surface of a glass device. These probes dissolve back into solution once in contact with the supplied hybridization buffer, whilst denaturation of the probes and target DNA occurs simultaneously under the device when heated. This approach not only simplifies the whole FISH procedure but also render it safe and quicker to use.
*All Probes have multiple regulatory status CE-IVD or RUO. Availability is dependent on local country regulatory status. Please contact your local Sysmex Representative for more information.
Benefits of the Multiprobe
This system allows multiple FISH probes to be hybridized on the same slide in a spatially separated manner allowing rapid screening of a patient sample for multiple DNA target sequences in a single FISH analysis.
The assay is supplied in a kit format of 2,5 or 10 devices and includes hybridization solution, DAPI counterstain, template slides, a hybridization chamber and full instructions for use. The kit even contains a unique liquid crystal display slide surface thermometer for accurate temperature measurement of the denaturation surface.